Amphetamine is known to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit various P450 isozymes and other enzymes hasn't been sufficiently elucidated. In vitro experiments with human microsomes suggest insignificant inhibition of CYP2D6 by amphetamine and slight inhibition of CYP1A2, 2D6, and 3A4 by a